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MRCPUK SEND Exam Syllabus Topics:
| Section | Objectives |
|---|---|
| Thyroid Disorders | - Thyroid Disease
|
| Diabetes Mellitus | - Diagnosis and Classification
|
| General Endocrinology | - Integrated Clinical Practice
|
| Reproductive Endocrinology | - Gonadal Disorders
|
| Pituitary and Hypothalamic Disorders | - Pituitary Disease
|
| Calcium and Bone Metabolism | - Parathyroid and Metabolic Bone Disease
|
| Adrenal Disorders | - Adrenal Disease
|
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 33-year-old woman was seen for diabetes review 2 months after her first pregnancy. Diabetes mellitus had been diagnosed at 18 weeks' gestation. She had experienced no symptoms; routine urinalysis had shown glucose 4+, with no ketones, and her fasting blood glucose concentration was 6.2 mmol/L (3.0-6.0), rising to 13.5 mmol/L (<7.8) in a 75-g oral glucose tolerance test. She had been treated with insulin during the pregnancy, and stopped after delivery. Her mother and maternal aunt had been treated for type 2 diabetes mellitus, and a maternal uncle for type 1 diabetes. Her body mass index was 23.7 kg/m2 (18-25).
Without insulin she remained well, with no osmotic symptoms, no weight loss and no ketosis.
Investigations:
fasting plasma glucose8.4 mmol/L (3.0-6.0)
haemoglobin A1c68 mmol/mol (20-42)
oral glucose tolerance test (75 g):
fasting plasma glucose7.9 mmol/L (3.0-6.0)
2-h plasma glucose13.8 mmol/L (<7.8)
serum insulin72 pmol/L (<186)
serum C-peptide945 pmol/L (180-360)
A trial of therapy with gliclazide 40 mg once daily led to a significant improvement in her blood glucose.
What is the most likely cause of her diabetes?
A) type 2 diabetes mellitus
B) type 1 diabetes mellitus
C) latent autoimmune diabetes in adulthood
D) maturity-onset diabetes of the young caused by HNF-1? mutation
E) maturity-onset diabetes of the young caused by glucokinase mutation
2. A 32-year-old man presented with medullary thyroid cancer, treated by total thyroidectomy. He had a past history of primary hyperparathyroidism, treated by selective parathyroidectomy. Postoperatively, plasma calcitonin was undetectable and serum calcium was in the normal range.
Investigations:
RET genotypeheterozygote codon 634 C>T mutation
What is the most appropriate approach to annual screening for phaeochromocytoma?
A) biochemical screening
B) MIBG scanning
C) octreotide scanning
D) MR scan of adrenal glands
E) CT scan of adrenal glands
3. A 19-year-old man was seen in the diabetes clinic. He had lost 2 kg in weight since the diagnosis of diabetes mellitus 18 months previously. At presentation, his body mass index was 33 kg/m2 (18-25), his random plasma glucose was 18.0 mmol/L and his haemoglobin A1c was 56 mmol/mol (20-42). He was taking gliclazide, and metformin had been added later. His father and grandfather had developed diabetes mellitus during their twenties.
Investigations:
haemoglobin A1c56 mmol/mol (20-42)
serum C-peptide301 pmol/L (180-360)
anti-glutamic acid decarboxylase (GAD)
antibodiesnegative
What is the most likely diagnosis?
A) type 2 diabetes mellitus
B) type 1 diabetes mellitus
C) latent-onset diabetes of autoimmunity
D) maturity-onset diabetes of the young
E) chronic pancreatitis
4. A 26-year-old physiologist was seen in the diabetes outpatient clinic. She had type 1 diabetes mellitus of 9 months' duration, treated with subcutaneous insulin.
She asked what symptoms of hypoglycaemia she might experience.
In what order are responses to hypoglycaemia most likely to occur as blood glucose falls?
A) neuroglycopenia, autonomic, counter-regulatory hormones
B) autonomic, counter-regulatory hormones, neuroglycopenia
C) counter-regulatory hormones, autonomic, neuroglycopenia
D) autonomic, neuroglycopenia, counter-regulatory hormones
E) counter-regulatory hormones, neuroglycopenia, autonomic
5. A 27-year-old woman with type 1 diabetes mellitus was invited to attend a structured education (e.g. DAFNE) coursE.
Which quality of life domain is most affected when a person is found to have type 1 diabetes mellitus?
A) working life and work-related opportunities
B) enjoyment of leisure activities
C) family life
D) freedom to eat as one wishes
E) sex life
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: A | Question # 3 Answer: D | Question # 4 Answer: C | Question # 5 Answer: D |
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